Nothing in the world can make Garfield get involved in anything besides eating, until the muscular super cat Garzooka comes crashing into Cartoon World from the Comic Book universe with terrifying news. Garfield summons up the willpower to join his superhero Garzooka in a fight to save their worlds.
Garfield emerges victorious at the end of every single Fun Fest, a competition for the best in comic strip characters. It's a given; he can do it with his paws tied behind his back. But this year, it looks like a dashing new contestant by the name of Ramone is going to give everyone's favorite fat cat a run for his lasagna, especially after the G-Man's usual partner-in-fun, Arlene, decides to pair.
Garfield is back with a new look. Tired with his routine as a comic strip star, Garfield escapes the page and heads into the "real world." While living the low-key life of a real housecat, he learns his comic will be cancelled if he doesn't return before the newspaper goes to print. The video games will follow the storyline as Garfield plows through obstacles to make his way back home.