Favino was born in Rome, Italy. He has appeared in more than forty Europeanfilmsandtelevision series' since the early 1990s, includingGabriele Muccino'sThe Last Kiss,Gianni Amelio'sThe Keys to the House,Giuseppe Tornatore'sThe Unknown WomanandFerzan Özpetek'sSaturn in Opposition. In1999he starred in theHBOfilmExcellent Cadavers, adaptation ofAlexander Stille'snovel of the same name. He received theDavid di Donatelloaward - Italian equivalent of the Oscar - in 2006 for his role in the crime filmRomanzo Criminale, directed byMichele Placido.
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