World-famous detective Benoit Blanc heads to Greece to peel back the layers of a mystery surrounding a tech billionaire and his eclectic crew of friends.
After tinkering with a box he bought while abroad, sexual deviant Frank inadvertently opens a portal to hell, where fetish-demons led by Pinhead tear his body apart. When Frank’s brother and his wife move into his house, a skeletal Frank appears to his sister-in-law and asks her to supply him with corpses for his regeneration.
A young woman struggling with addiction comes into possession of an ancient puzzle box, unaware that its purpose is to summon the Cenobites, a group of sadistic supernatural beings from another dimension.
Three generations of the same family deal with the consequences of unleashing the forces of hell.
Pinhead is trapped in the Pillar of Souls. Fortunately for him it is bought by a young playboy who owns his own nightclub. Pinhead busies himself escaping by getting the playboy to lure victims to his presence so he can use their blood. Once free, he seeks to destroy the puzzle box so he need never return to Hell, but a female reporter is investigating the grisly murders and stands in his way.
Two friends in Mexico discover the Lament Configuration and unleash Pinhead, but one decides to try to survive by swapping himself with someone else. Once they go missing, family members go in search of them, but find Pinhead instead.
In London, after investigating crack addicted junkies for an article in her newspaper, Amy Klein watches a bizarre videotape where an underground group of youngsters in Bucharest apparently become zombies. Amy finds Marla dead with a puzzle cube in her hands. She brings the object to her hotel room, and opens it, beginning her journey to hell.
Doctor Channard is sent a new patient, a girl warning of the terrible creatures that have destroyed her family, Cenobites who offer the most intense sensations of pleasure and pain. But Channard has been searching for the doorway to Hell for years, and Kirsty must follow him to save her father and witness the power struggles among the newly damned.
Maria's family give her a puzzle for her 50th birthday, and she loves it. Not only does the patient housewife have fun solving the puzzle, she's also really good at them. Overflowing with enthusiasm for her new-found passion, she goes back to the shop where they bought the gift for another puzzle. There her eye is caught by a notice on the message board: Partner for puzzle tournament wanted. Maria musters her courage and, despite her family's misgivings, answers the announcement.
Drug addict Kait flees to a house in the woods to self-rehabilitate, where her sister Olivia joins to document the process, but the house's layout begins to change, trapping them inside an inescapable puzzle box of a house.
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