The Hope Diamond Mystery is a 1921 American 15-chapter action film serial directed by Stuart Paton and featuring Grace Darmond, George Chesebro, May Yohe, and Boris Karloff. The screenplay was written by Charles Goddard and John B. Clymer, based on an autobiographical story by May Yohe (who also co-stars as herself in the serial). Chapter One premiered on February 19, 1921, and the final chapter was shown on May 29, 1921. The film survives with a copy at the Library of Congress, which includes all of the hand-tinted color sequences as well. ()